2025
- Inmunidad en declive: Cómo el envejecimiento remodela la respuesta inmune adaptativa
Dinatale, B., Bulfoni Balbi, C., González, F. B., Pacini, M. F., Moreno, M. A., Lioi, S., & Pérez, A. R. (2025). Inmunidad en declive: Cómo el envejecimiento remodela la respuesta inmune adaptativa. Revista De La Facultad De Ciencias Médicas. Universidad Nacional De Rosario., 4. https://doi.org/10.35305/fcm.v4i.134
- Regulated expression of galectins 1 and 3 IS associated with dysregulated T cell responses in pulmonary and pleural tuberculosis
Imhoff M, Diab MN, Gallucci G, Stupirski JC, Díaz A, Bongiovanni B, Bertola D, Lioi S, Bottasso O, Rabinovich GA, Bay ML, D’Attilio LD. Regulated expression of galectins 1 and 3 IS associated with dysregulated T cell responses in pulmonary and pleural tuberculosis. Med Microbiol Immunol. 2025 Sep 15;214(1):42. doi: 10.1007/s00430-025-00856-w. PMID: 40952516.
- Progression of Trypanosoma cruzi Dm28c Strain Infection in a BALB/c Mouse Experimental Model
de Hernández, M. A., Villar, S. R., & Cribb, P. (2025). Progression of Trypanosoma cruzi Dm28c Strain Infection in a BALB/c Mouse Experimental Model. Parasitologia, 5(3), 47. https://doi.org/10.3390/parasitologia5030047
- A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer
Dilasser F, Rose L, Quemener A, Ferrandez Y, Hassoun D, Rousselle M, Bergereau H, Lambot SM, Anselmino LE, Trouillet C, Andre G, Maillasson M, Croyal M, Riviere M, Dubreuil D, Collet S, Souaze F, Campone M, Patsouris A, Mortier E, Marquez MM, Juin P, Lebreton J, Tessier A, Cherfils J, Loirand G, Sauzeau V. (2025). A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer. Cell Rep Med. Jul 15;6(7):102233. doi: 10.1016/j.xcrm.2025.102233. Epub 2025 Jul 8. PMID: 40633540; PMCID: PMC12281424.
- Sexual dimorphism-driven differences are overcome in a preclinical vaccine model against Trypanosoma cruzi. Front. Immunol
Bulfoni BalbiC, Pacini MF, Dinatale B, Farré C,Cacik P, Prochetto E, González FB, Marcipar I, Cabrera Gand Pérez AR. (2025). Sexual dimorphism-driven differences are overcome in a preclinical vaccine model against Trypanosoma cruzi. Front. Immunol. 16:1526573. doi: 10.3389/fimmu.2025.1526573
- Altered levels of angiogenin and tRNA-derived fragments associate with severe asthma
Claus, C., Grosso, J. B., Maraval, M. B., Ardusso, M., Bottasso, O. A., Maes, T., Bracke, K., Brusselle, G., Ibañez, M., Ardusso, L. R. F., & Spinelli, S. V. (2025). Altered levels of angiogenin and tRNA-derived fragments associate with severe asthma. Scientific Reports, 15, 18808. doi.org/10.1038/s41598-025-03314-y
- Diversity of hypervirulent Klebsiella pneumoniae clones causing cryptogenic liver abscesses and metastatic complications in Argentina
Esteban C. Nannini, Matías Lahitte, Pablo Scapellato, Corina Nemirosvky, Marcelo Zylberman, Andrea Vila, Viviana Rodríguez, Roman Zucchi, Analia Mykietiuk, Valeria David, Adriana Limansky, Patricia Marchiaro, Mariángel Rinaudo. Diversity of hypervirulent Klebsiella pneumoniae clones causing cryptogenic liver abscesses and metastatic complications in Argentina, Revista Argentina de Microbiología,2025, ISSN 0325-7541, https://doi.org/10.1016/j.ram.2024.11.006.
- Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease
Pérez Ana R. , Bottasso Oscar A. , Santucci Natalia E. Front Endocrinol. 2025 Feb. doi: 10.3389/fendo.2025.1538376
- Un empirista en pleno medioevo
Oscar Bottasso. 2025 Feb. Intramed
- Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for inflammation and cardiac hypertrophy
González FB, Pacini A, Castro A, Lioi S, Villar SR, D’Attilio L, Leiva RD, Favaloro L, Bottasso OA, Vigliano CA, Pérez AR. Front Endocrinol (Lausanne). 2025 Jan 30;16:1486772. doi: 10.3389/fendo.2025.1486772.
- Activation of the Nrf2/HO-1 pathway restores N-acetylcysteine-induced impairment of the hypothalamus-pituitary-adrenal axis negative feedback by up-regulating GRα expression and down-regulating GRβ expression into pituitary glands
Chaves AS, Ventura RD, Pacini MF, Magalhães NS, Silva PMRE, Martins MA, Pérez AR, Carvalho VF. Front Endocrinol (Lausanne). 2025 Jan 27;16:1500630. doi: 10.3389/fendo.2025.1500630.
2024
- Lack of differences in outcomes between three immunosuppression protocols in the first year post pediatric liver transplantation. A multicenter study.Costaguta AC, Costaguta GA, Rumbo C, Gondolesi G, D’Agostino D, Pallito MB, Bottasso O, Álvarez F.Liver Transpl. 2024 Jul 2. doi: 10.1097/LVT.0000000000000427. Online ahead of print.
- Characteristics of endemic human coronavirus infections during times of COVID-19 pandemic.
Crocci EE, Schreiner D, García EA, Nannini EC, Cobos M, Doubik P, Balbuena JP, Romandetta A, Cooke B, Alzogaray MF, Baumeister E, Mykietiuk A.Medicina (B Aires). 2024;84(1):102-107.
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Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach.
Villar SR, Herreros-Cabello A, Callejas-Hernández F, Maza MC, Del Moral-Salmoral J, Gómez-Montes M, Rodríguez-Angulo HO, Carrillo I, Górgolas M, Bosch-Nicolau P, Molina I, Pérez-Molina JA, Monge-Maillo B, Bottasso OA, Beloscar J, Pérez AR, Fresno M, Gironès N.Sci Rep. 2024 Jan 12;14(1):1187. doi: 10.1038/s41598-024-51487-9.
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Brain-Thymus Connections in Chagas Disease.
González FB, Savino W, Pérez AR.Neuroimmunomodulation. 2024;31(1):78-88. doi: 10.1159/000538220. Epub 2024 Apr 9.
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Viano ME, Baez NS, Savid-Frontera C, Baigorri RE, Dinatale B, Pacini MF, Bulfoni Balbi C, Gonzalez FB, Fozzatti L, Lidón NL, Young HA, Hodge DL, Cerban F, Stempin CC, Pérez AR, Rodriguez-Galán MC.Microbes Infect. 2024 Jul-Aug;26(5-6):105337. doi: 10.1016/j.micinf.2024.105337. Epub 2024 Apr 13.
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Association between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease.
Ambrosio LF, Volpini X, Quiroz JN, Brugo MB, Knubel CP, Herrera MR, Fozzatti L, Avila Pacheco J, Clish CB, Takenaka MC, Beloscar J, Theumer MG, Quintana FJ, Perez AR, Motrán CC.Front Immunol. 2024 Jan 12;14:1267641. doi: 10.3389/fimmu.2023.1267641. eCollection 2023.
- Intranasal Trans-Sialidase Vaccine Mitigates Acute and Chronic Pathology in a Preclinical Oral Chagas Disease Model
Pacini MF, Bulfoni Balbi C, Dinatale B, Farré C, Cacik P, Gonzalez FB, Marcipar I, Pérez AR. (2024). Intranasal Trans-Sialidase Vaccine Mitigates Acute and Chronic Pathology in a Preclinical Oral Chagas Disease Model. Vaccines, 12(10), 1171. https://doi.org/10.3390/vaccines12101171
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D-phenotype caused by a novel RHCE null allele.
Principi C, Trucco Boggione C, Ensinck A, Posner V, Luján Brajovich M, Stettler S, Mattaloni S, Biondi C, Cotorruelo C. Transfusion. 2024 Feb;64(2):E3-E5. doi: 10.1111/trf.17698. Epub 2024 Jan 5.
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Borgna E, Prochetto E, Gamba JC, Vermeulen EM, Poncini CV, Cribb P, Pérez AR, Marcipar I, González FB, Cabrera G. (2024). Control of myeloid-derived suppressor cell dynamics potentiates vaccine protection in multiple mouse models of Trypanosoma cruzi infection. Frontiers in Immunology, 15, 1484290. https://doi.org/10.3389/fimmu.2024.1484290
- Protective Efficacy of the Epitope-Conjugated Antigen N-Tc52/TSkb20 in Mitigating Trypanosoma cruzi Infection through CD8+ T-Cells and IFNγ Responses
Vázquez ME, Zabala BA, Mesías AC, Biscari L, Kaufman CD, Alloatti A, Siano F, Picariello G, Corbalán NS, Lenis BA, Toscano MA, Parodi CM, Brandán CMP, Acuña L. (2024). Protective Efficacy of the Epitope-Conjugated Antigen N-Tc52/TSkb20 in Mitigating Trypanosoma cruzi Infection through CD8+ T-Cells and IFNγ Responses. Vaccines, 12(6), 621. https://doi.org/10.3390/vaccines12060621
- A novel SNV on a previously reported hybrid RHCE background is responsible for an Rh haplotype potentially involved in the generation of an Rh null phenotype
Principi C, Trucco Boggione C, Mestra Campo B, Posner V, Zani N, Luján Brajovich M, Villanueva M, Mattaloni SM, Ensinck A, Biondi C, Cotorruelo C. (2022). A novel SNV on a previously reported hybrid RHCE background is responsible for an Rh haplotype potentially involved in the generation of an Rh null phenotype. Transfusion, 62(11), E70-E72. https://doi.org/10.1111/trf.17126
- Overcoming Therapy Resistance in Colorectal Cancer: Targeting the Rac1 Signaling Pathway as a Potential Therapeutic Approach
Anselmino LE, Malizia F, Avila A, Cesatti Laluce N, Mamberto M, Zanotti LC, Farré C, Sauzeau V, Menacho Márquez M. (2024). Overcoming Therapy Resistance in Colorectal Cancer: Targeting the Rac1 Signaling Pathway as a Potential Therapeutic Approach. Cells, 13(21), 1776. https://doi.org/10.3390/cells13211776
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Isoprenylcysteine carboxyl methyltransferase (ICMT) promotes invadopodia formation and metastasis in cancer cells
Borini Etichetti C, Arel Zalazar E, Di Benedetto C, Cocordano N, Valente S, Bicciato S, Menacho-Márquez M, Larocca MC, Girardini J. (2024). Isoprenylcysteine carboxyl methyltransferase (ICMT) promotes invadopodia formation and metastasis in cancer cells. Biochimie, 222, 28-36. https://doi.org/10.1016/j.biochi.2024.01.015
- Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis
Hidalgo F, Ferretti AC, Etichetti CB, Baffo E, Pariani AP, Maknis TR, Bussi J, Girardini JE, Larocca MC, Favre C. (2024). Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis. Scientific Reports, 14(1), 21275. https://doi.org/10.1038/s41598-024-72309-y
2023
- Intranasal trans-sialidase-based vaccine against Trypanosoma cruzi triggers a mixed cytokine profile in the nasopharynx-associated lymphoid tissue and confers local and systemic immunogenicity
Pacini MF, Balbi CB, Dinatale B, González FB, Prochetto E, De Hernández MA, Cribb P, Farré C, Espariz M, Blancato VS, Magni C, Marcipar I, Pérez AR. Intranasal trans-sialidase-based vaccine against Trypanosoma cruzi triggers a mixed cytokine profile in the nasopharynx-associated lymphoid tissue and confers local and systemic immunogenicity. Acta Trop. 2023 May;241:106889. doi: 10.1016/j.actatropica.2023.106889. Epub 2023 Mar 7. PMID: 36893830.
- Ready for new waves: optimizing SARS-CoV-2 variants monitoring in pooled samples with droplet digital PCR.
Pacini A, Paredes F, Heckel S, Ibarra G, Petreli MV, Perez M, Agnella Y, Piskulic L, Allasia MB, Caprile L, Colaneri A, Sesma J. Front Public Health. 2024 Jan 12;11:1340420. doi: 10.3389/fpubh.2023.1340420. eCollection 2023.
- Antibodies to SARS-CoV2 induced by vaccination and infection correlate with protection against the infection.
Flor N, García MI, Molineri A, Bottasso O, Diez C, Veaute C. Vaccine. 2023 Nov 22;41(48):7206-7211. doi: 10.1016/j.vaccine.2023.10.038. Epub 2023 Oct 24.
- Impact of population mobility on the behavior of respiratory viruses during the COVID-19 pandemic.
Cobos M, Nannini EC, Balbuena JP, Crocci EE, Schreiner D, Garcia EA, Chapartegui S, Doubik P, Romandetta A, Cooke B, Alzogaray MF, Baumeister E, Mykietiuk A.Medicina (B Aires). 2023;83(5):719-726.
- The long-term antibody response after SARS-CoV-2 prime-boost vaccination in healthy individuals. The positive influence of extended between-dose intervals and heterologous schedule.
Naidich G, Santucci NE, Pezzotto SM, Ceccarelli EA, Bottasso OA, Perichón AM.Front Immunol. 2023 Apr 17;14:1141794. doi: 10.3389/fimmu.2023.1141794. eCollection 2023.
- Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle.
Kaufman CD, Farré C, Biscari L, Pérez AR, Alloatti A.Front Cell Dev Biol. 2023 Dec 21;11:1260423. doi: 10.3389/fcell.2023.1260423. eCollection 2023.
- Lipophilic modification of salirasib modulates the antiproliferative and antimigratory activity.
Ballari MS, O J Porta E, Zalazar EA, Etichetti CMB, Padrón JM, Girardini JE, Labadie GR.Bioorg Med Chem. 2023 Sep 7;92:117417. doi: 10.1016/j.bmc.2023.117417. Epub 2023 Jul 17.
- Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial.
O’Halloran JA, Ko ER, Anstrom KJ, Kedar E, McCarthy MW, Panettieri RA Jr, Maillo M, Nunez PS, Lachiewicz AM, Gonzalez C, Smith PB, de Tai SM, Khan A, Lora AJM, Salathe M, Capo G, Gonzalez DR, Patterson TF, Palma C, Ariza H, Lima MP, Blamoun J, Nannini EC, Sprinz E, Mykietiuk A, Alicic R, Rauseo AM, Wolfe CR, Witting B, Wang JP, Parra-Rodriguez L, Der T, Willsey K, Wen J, Silverstein A, O’Brien SM, Al-Khalidi HR, Maldonado MA, Melsheimer R, Ferguson WG, McNulty SE, Zakroysky P, Halabi S, Benjamin DK Jr, Butler S, Atkinson JC, Adam SJ, Chang S, LaVange L, Proschan M, Bozzette SA, Powderly WG; ACTIV-1 IM Study Group Members.JAMA. 2023 Jul 25;330(4):328-339. doi: 10.1001/jama.2023.11043.
- Studies on the contribution of PPAR Gamma to tuberculosis physiopathology.
Díaz A, D’Attilio L, Penas F, Bongiovanni B, Massa E, Cevey A, Santucci N, Bottasso O, Goren N, Bay ML.Front Cell Infect Microbiol. 2023 Apr 28;13:1067464. doi: 10.3389/fcimb.2023.1067464. eCollection 2023.
- The high identity of the Trypanosoma cruzi Group-I of trans-sialidases points them as promising vaccine immunogens.
Pacini MF, Perdomini A, Bulfoni Balbi C, Dinatale B, Herrera FE, Perez AR, Marcipar I.Proteins. 2023 Oct;91(10):1444-1460. doi: 10.1002/prot.26537. Epub 2023 Jun 16.
- Comparative analysis of clinical characteristics, evolution and mortality of hospitalized patients with COVID-19 during the first and second wave of the pandemic (ECCOVID Study).
Córdova E, Mykietiuk A, De Vedia L, Bacelar B, Cáceres MF, Nemirovsky C, Contreras R, Alzogaray MF, Nannini E, Consalvo MF, Soler Puy L, Scapellato PG, Barcelona L, Golikow ML, Piñeiro MF, Miño HJ, Cabral M, Lamponi Tappata L, Lopardo G, Sued O, Stryjewski ME; Grupo ECCOVID-SADI.Medicina (B Aires). 2023;83(4):551-557.
- Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia.
Holland TL, Cosgrove SE, Doernberg SB, Jenkins TC, Turner NA, Boucher HW, Pavlov O, Titov I, Kosulnykov S, Atanasov B, Poromanski I, Makhviladze M, Anderzhanova A, Stryjewski ME, Assadi Gehr M, Engelhardt M, Hamed K, Ionescu D, Jones M, Saulay M, Smart J, Seifert H, Fowler VG Jr; ERADICATE Study Group.N Engl J Med. 2023 Oct 12;389(15):1390-1401. doi: 10.1056/NEJMoa2300220. Epub 2023 Sep 27.
- Synuclein Proteins in Cancer Development and Progression.
Zanotti LC, Malizia F, Cesatti Laluce N, Avila A, Mamberto M, Anselmino LE, Menacho-Márquez M. Biomolecules. 2023 Jun 12;13(6):980. doi: 10.3390/biom13060980.
- Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents.
Bruna-Haupt EF, Perretti MD, Garro HA, Carrillo R, Machín F, Lorenzo-Castrillejo I, Gutiérrez L, Vega-Hissi EG, Mamberto M, Menacho-Marquez M, Fernández CO, García C, Pungitore CR.ACS Omega. 2023 Jul 13;8(29):26479-26496. doi: 10.1021/acsomega.3c03181. eCollection 2023 Jul 25.
- Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers.
Anselmino LE, Baglioni MV, Reynoso G, Rozados VR, Scharovsky OG, Rico MJ, Menacho-Márquez M.Sci Rep. 2023 May 16;13(1):7923. doi: 10.1038/s41598-023-34793-6.
- The p53 tumor suppressor regulates AKR1B1 expression, a metastasis-promoting gene in breast cancer.
Di Benedetto C, Borini Etichetti C, Cocordano N, Cantoia A, Arel Zalazar E, Bicciato S, Menacho-Márquez M, Rosano GL, Girardini J. Front Mol Biosci. 2023 Sep 14;10:1145279. doi: 10.3389/fmolb.2023.1145279. eCollection 2023.
- The relationship between host defense peptides and adrenal steroids. An account of reciprocal influences.
Díaz A, Diab M, Mata-Espinosa D, Bini E, D’Attilio L, Bottasso O, Hernández-Pando R, Bay ML,Bongiovanni B. Cytokine. 2023 Aug;168:156229. doi: 10.1016/j.cyto.2023.156229. Epub 2023 May 25.
- Factors associated with mortality among hospitalized patients with COVID-19 disease treated with convalescent plasma.
Perichon AM, Acosta A, Di Tulio L, Munuce MJ, Pezzotto S, Bottasso O, Nannini EC.mBio. 2023 Dec 19;14(6):e0177723. doi: 10.1128/mbio.01777-23. Epub 2023 Nov 8.
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Sec22b-dependent antigen cross-presentation is a significant contributor of T cell priming during infection with the parasite Trypanosoma cruzi
Biscari L, Maza MC, Farré C, Kaufman CD, Amigorena S, Fresno M, Gironès N, Alloatti A. (2023). Sec22b-dependent antigen cross-presentation is a significant contributor of T cell priming during infection with the parasite Trypanosoma cruzi. Frontiers in Cell and Developmental Biology, 11, 1138571. https://doi.org/10.3389/fcell.2023.1138571 -
The p53 tumor suppressor regulates AKR1B1 expression, a metastasis-promoting gene in breast cancer
Di Benedetto C, Borini Etichetti C, Cocordano N, Cantoia A, Arel Zalazar E, Bicciato S, Menacho-Márquez M, Rosano GL, Girardini J. (2023). The p53 tumor suppressor regulates AKR1B1 expression, a metastasis-promoting gene in breast cancer. Frontiers in Molecular Biosciences, 10, 1145279. https://doi.org/10.3389/fmolb.2023.1145279
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Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents
Bruna-Haupt EF, Perretti MD, Garro HA, Carrillo R, Machín F, Lorenzo-Castrillejo I, Gutiérrez L, Vega-Hissi EG, Mamberto M, Menacho-Marquez M, Fernández CO, García C, Pungitore CR. (2023). Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents. ACS Omega, 8(29), 26479-26496. https://doi.org/10.1021/acsomega.3c03181
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Synuclein Proteins in Cancer Development and Progression
Zanotti LC, Malizia F, Cesatti Laluce N, Avila A, Mamberto M, Anselmino LE, Menacho-Márquez M. (2023). Synuclein Proteins in Cancer Development and Progression. Biomolecules, 13(6), 980. https://doi.org/10.3390/biom13060980
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Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers
Anselmino LE, Baglioni MV, Reynoso G, Rozados VR, Scharovsky OG, Rico MJ, Menacho-Márquez M. (2023). Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers. Scientific Reports, 13(1), 7923. https://doi.org/10.1038/s41598-023-34793-6
2022
- Chagas disease in children from the Gran Chaco region: A bibliographic appraisal
Mendicino, D., & Bottasso, O. (2022). Chagas disease in children from the Gran Chaco region: A bibliographic appraisal. Tropical Doctor, 52(4), 560–562. https://doi.org/10.1177/00494755221103002
- The immunoregulatory actions of DHEA in tuberculosis, a tool for therapeutic intervention?
Bongiovanni, B., Díaz, A., Santucci, N., D’Attilio, L. D., Bottasso, O., Hernández Pando, R., & Bay, M. L. (2022). The immunoregulatory actions of DHEA in tuberculosis, a tool for therapeutic intervention? Frontiers in Endocrinology, 13, 892270. https://doi.org/10.3389/fendo.2022.892270
- Differential expression of genes regulated by the glucocorticoid receptor pathway in patients with pulmonary tuberculosis
Gallucci, G., Díaz, A., Fernández, R. D. V., Bongiovanni, B., Imhoff, M., Massa, E., Santucci, N., Bértola, D., Lioi, S., Bay, M. L., Bottasso, O., & D’Attilio, L. (2022). Differential expression of genes regulated by the glucocorticoid receptor pathway in patients with pulmonary tuberculosis. Life Sciences, 301, 120614. https://doi.org/10.1016/j.lfs.2022.120614
- The potential implication of decreased DHEA levels in the pathophysiology of chronic Chagas cardiomyopathy
Bottasso, O. (2022). The potential implication of decreased DHEA levels in the pathophysiology of chronic Chagas cardiomyopathy. International Journal of Cardiology, 350, 92–93. https://doi.org/10.1016/j.ijcard.2022.01.012
- Central nervous system commitment in Chagas disease
Useche Y, Pérez AR, de Meis J, Bonomo A, Savino W. (2022). Central nervous system commitment in Chagas disease. Frontiers in Immunology, 13, 975106. https://doi.org/10.3389/fimmu.2022.975106
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Immunization With Lipopolysaccharide-Activated Dendritic Cells Generates a Specific CD8+ T Cell Response That Confers Partial Protection Against Infection With Trypanosoma cruzi
Biscari L, Kaufman CD, Farré C, Huhn V, Pacini MF, Balbi CB, Gómez KA, Pérez AR, Alloatti A. (2022). Immunization With Lipopolysaccharide-Activated Dendritic Cells Generates a Specific CD8+ T Cell Response That Confers Partial Protection Against Infection With Trypanosoma cruzi. Frontiers in Cellular and Infection Microbiology, 12, 897133. https://doi.org/10.3389/fcimb.2022.897133
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Assessment of a combined treatment with a therapeutic vaccine and benznidazole for the Trypanosoma cruzi chronic infection
Prochetto E, Bontempi I, Rodeles L, Cabrera G, Vicco M, Cacik P, Pacini MF, Pérez Gianeselli M, Pérez AR, Marcipar I. (2022). Assessment of a combined treatment with a therapeutic vaccine and benznidazole for the Trypanosoma cruzi chronic infection. Acta Tropica, 229, 106334. https://doi.org/10.1016/j.actatropica.2022.106334
- Editor’s Note: Peptide Aptamers Targeting Mutant p53 Induce Apoptosis in Tumor Cells
Guida E, Bisso A, Fenollar-Ferrer C, Napoli M, Anselmi C, Girardini JE, Carloni P, Sal GD. (2022). Editor’s Note: Peptide Aptamers Targeting Mutant p53 Induce Apoptosis in Tumor Cells. Cancer Research, 82(9), 1844. https://doi.org/10.1158/0008-5472.CAN-22-0459
2021
- Editorial: Neuroendocrine-Immunological Interactions in Health and Disease
Pérez AR, Maya-Monteiro CM, Carvalho VF. (2021). Editorial: Neuroendocrine-Immunological Interactions in Health and Disease. Frontiers in Endocrinology, 12, 718893. https://doi.org/10.3389/fendo.2021.718893
- Bioinformática y bioética. El desafío de complementarlas
Bottasso, O., Mendicino, D., Perez, A. R., & Moretti, E. (2021). [Bioinformática y bioética. El desafío de complementarlas]. Medicina (Buenos Aires), 81(6), 1091–1092.
- Enhanced migratory capacity of T lymphocytes in severe chagasic patients is correlated with VLA-4 and TNF-α expression
Berbert, L. R., González, F. B., Villar, S. R., Vigliano, C., Lioi, S., Beloscar, J., Bottasso, O. A., Silva-Barbosa, S. D., Savino, W., & Pérez, A. R. (2021). Enhanced migratory capacity of T lymphocytes in severe chagasic patients is correlated with VLA-4 and TNF-α expression. Frontiers in Cellular and Infection Microbiology, 11, 713150. https://doi.org/10.3389/fcimb.2021.713150
- Increased levels of circulating LPS during tuberculosis prevails in patients with advanced pulmonary involvement
Gallucci, G., Santucci, N., Díaz, A., Bongiovanni, B., Bértola, D., Gardeñez, W., Rassetto, M., Bay, M. L., Bottasso, O., & D’Attilio, L. (2021). Increased levels of circulating LPS during tuberculosis prevails in patients with advanced pulmonary involvement. PLoS ONE, 16(9), e0257214. https://doi.org/10.1371/journal.pone.0257214
- Trypanocidal therapy among children infected by Trypanosoma cruzi: Serological and electrocardiographic changes over a mean twenty-five-years follow-up period
Suasnábar, S., Olivera, L. V., Arias, E., Bizai, M. L., Bottasso, O., Arias, E., & Fabbro, D. (2021). Trypanocidal therapy among children infected by Trypanosoma cruzi: Serological and electrocardiographic changes over a mean twenty-five-years follow-up period. Acta Tropica, 222, 106050. https://doi.org/10.1016/j.actatropica.2021.106050
- Levels of anti-B13 antibodies over time in a cohort of chronic infected by Trypanosoma cruzi: Its relationship with specific treatment and clinical status
Olivera, V., Bizai, M. L., Arias, E., Suasnábar, S., Bottasso, O., Marcipar, I., & Fabbro, D. (2021). Levels of anti-B13 antibodies over time in a cohort of chronic infected by Trypanosoma cruzi: Its relationship with specific treatment and clinical status. Acta Tropica, 218, 105908. https://doi.org/10.1016/j.actatropica.2021.105908
- Chagas disease reactivation in rheumatologic patients: Association with immunosuppressive therapy and humoral response
Ringer, A., Ruffino, J. P., Leiva, R., Cuadranti, N., Argento, M. C., Martínez, M. F., Rolla, I., Chulibert, S., Carbone, D., Palatnik, M., Cortese, M. N., Lagrutta, M., Córdoba, L., González, F. B., Pacini, M. F., Villar, S. R., Águila, D., Bottasso, O. A., Pérez, A. R., & Abdala, M. (2021). Chagas disease reactivation in rheumatologic patients: Association with immunosuppressive therapy and humoral response. Clinical Rheumatology, 40(7), 2955–2963. https://doi.org/10.1007/s10067-021-05581-2
- Levels of seminal tRNA-derived fragments from normozoospermic men correlate with the success rate of ART
Grosso JB, Zoff L, Calvo KL, Maraval MB, Perez M, Carbonaro M, Brignardello C, Morente C, Spinelli SV. Levels of seminal tRNA-derived fragments from normozoospermic men correlate with the success rate of ART. Mol Hum Reprod. 2021 Mar 24;27(4):gaab017. doi: 10.1093/molehr/gaab017. PMID: 33693947.
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Targeting Myeloid-Derived Suppressor Cells to Enhance a Trans-Sialidase-Based Vaccine Against Trypanosoma cruzi
Gamba JC, Roldán C, Prochetto E, Lupi G, Bontempi I, Poncini CV, Vermeulen M, Pérez AR, Marcipar I, Cabrera G. (2021). Targeting Myeloid-Derived Suppressor Cells to Enhance a Trans-Sialidase-Based Vaccine Against Trypanosoma cruzi. Frontiers in Cellular and Infection Microbiology, 11, 671104. https://doi.org/10.3389/fcimb.2021.671104
- A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus
Rincon S, Carvajal LP, Gomez-Villegas SI, Echeverri AM, Rios R, Dinh A, Pedroza C, Ordoñez KM, Nannini E, Sun Z, Fowler VG, Murray BE, Miller WR, Palzkill T, Diaz L, Arias CA, Reyes J. A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus. J Clin Microbiol. 2021 Mar 19;59(4):e01938-20. doi: 10.1128/JCM.01938-20. PMID: 33536292; PMCID: PMC8092731.
- New Functions of Vav Family Proteins in Cardiovascular Biology, Skeletal Muscle, and the Nervous System
Rodríguez-Fdez S, Lorenzo-Martín LF, Fabbiano S, Menacho-Márquez M, Sauzeau V, Dosil M, Bustelo XR. (2021). New Functions of Vav Family Proteins in Cardiovascular Biology, Skeletal Muscle, and the Nervous System. Biology, 10(9), 857. https://doi.org/10.3390/biology10090857
- Repositioning metformin and propranolol for colorectal and triple negative breast cancers treatment
Anselmino LE, Baglioni MV, Malizia F, Laluce NC, Etichetti CB, Marignac VLM, Rozados V, Scharovsky OG, Girardini J, Rico MJ, Menacho Márquez M. (2021). Repositioning metformin and propranolol for colorectal and triple negative breast cancers treatment. Scientific Reports, 11(1), 8091. https://doi.org/10.1038/s41598-021-87525-z
2020
- The SARS-CoV-2 Coronavirus and the COVID-19 Outbreak
Lauxmann MA, Santucci NE, Autrán-Gómez AM. The SARS-CoV-2 Coronavirus and the COVID-19 Outbreak. Int Braz J Urol. 2020 Jul;46(suppl.1):6-18. doi: 10.1590/S1677-5538.IBJU.2020.S101. PMID: 32549071; PMCID: PMC7719995.
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The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
Pérez AR, de Meis J, Rodriguez-Galan MC, Savino W. (2020). The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation. Frontiers in Immunology, 11, 1838. https://doi.org/10.3389/fimmu.2020.01838
- Evidence in favor of an alternative glucocorticoid synthesis pathway during acute experimental Chagas disease
da Silva Oliveira Barbosa, E., Roggero, E. A., González, F. B., Fernández, R. D. V., Carvalho, V. F., Bottasso, O. A., Pérez, A. R., & Villar, S. R. (2020). Evidence in favor of an alternative glucocorticoid synthesis pathway during acute experimental Chagas disease. Frontiers in Endocrinology, 10, 866. https://doi.org/10.3389/fendo.2019.00866
- Immune-neuroendocrine and metabolic disorders in human and experimental T. cruzi infection: New clues for understanding Chagas disease pathology
González, F. B., Villar, S. R., Pacini, M. F., Bottasso, O. A., & Pérez, A. R. (2020). Immune-neuroendocrine and metabolic disorders in human and experimental T. cruzi infection: New clues for understanding Chagas disease pathology. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, 1866(3), 165642. https://doi.org/10.1016/j.bbadis.2019.165642
- Evidence that changes in antimicrobial peptides during tuberculosis are related to disease severity, clinical presentation, specific therapy and levels of immune-endocrine mediators
Bongiovanni, B., Marín-Luevano, S., D’Attilio, L., Díaz, A., Fernández, R. D. V., Santucci, N., Bértola, D., Bay, M. L., Rivas-Santiago, B., & Bottasso, O. (2020). Evidence that changes in antimicrobial peptides during tuberculosis are related to disease severity, clinical presentation, specific therapy and levels of immune-endocrine mediators. Cytokine, 126, 154913. https://doi.org/10.1016/j.cyto.2019.154913
- 1. Local regulation of adrenal steroidogenesis: Subtle in vitro effects of IL-1β on the human cell line NCI-H295R steroid production along with changes in microRNA profile and orphan nuclear receptors NR4As
Santucci, N., Stampone, R., Brandão Ferreira da Silva, E., Villar, S., Spinelli, S., Linhares-Lacerda, L., Ribeiro-Alves, M., Bay, M. L., & Bottasso, O. (2020). Local regulation of adrenal steroidogenesis: Subtle in vitro effects of IL-1β on the human cell line NCI-H295R steroid production along with changes in microRNA profile and orphan nuclear receptors NR4As. Neuroimmunomodulation, 27(3), 131–141. https://doi.org/10.1159/000512325
- Evidence for a more disrupted immune-endocrine relation and cortisol immunologic influences in the context of tuberculosis and type 2 diabetes comorbidityFernández, R. D. V., Díaz, A., Bongiovanni, B., Gallucci, G., Bértola, D., Gardeñez, W., Lioi, S., Bertolin, Y., Galliano, R., Bay, M. L., Bottasso, O., & D’Attilio, L. (2020). Evidence for a more disrupted immune-endocrine relation and cortisol immunologic influences in the context of tuberculosis and type 2 diabetes comorbidity. Frontiers in Endocrinology, 11, 126. https://doi.org/10.3389/fendo.2020.00126
- Activation of PPARγ reduces N-acetyl-cysteine -induced hypercorticoidism by down-regulating MC2R expression into adrenal glands
Ventura RD, Chaves AS, Magalhães NS, Gonzalez FB, Pacini MF, Pérez AR, Silva PMR, Martins MA, Carvalho VF. (2020). Activation of PPARγ reduces N-acetyl-cysteine -induced hypercorticoidism by down-regulating MC2R expression into adrenal glands. Free Radical Biology and Medicine, 156, 137-143. https://doi.org/10.1016/j.freeradbiomed.2020.06.008
- Extensive clinical, serologic and molecular studies lead to the first reported Rhmod phenotype in Argentina
Mufarrege N, Franco N, Trucco Boggione C, Arnoni C, de Paula Vendrame T, Bartoli S, Ensinck A, Principi C, Lujan Brajovich M, Mattaloni S, Riquelme B, Biondi C, Castilho L, Cotorruelo C. (2020). Extensive clinical, serologic and molecular studies lead to the first reported Rhmod phenotype in Argentina. Transfusion, 60(7), 1373-1377. https://doi.org/10.1111/trf.15792
- The novel RHD c.325A>G single nucleotide variation found in Argentineans leads to a partial D phenotype
Mufarrege N, Trucco Boggione C, Puppo M, Ensinck A, Príncipi C, Brajovich ML, Mattaloni S, Biondi C, Kuperman S, Cotorruelo C. (2020). The novel RHD c.325A>G single nucleotide variation found in Argentineans leads to a partial D phenotype. Transfusion, 60(11), E43-E44. https://doi.org/10.1111/trf.16050
- VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
Lorenzo-Martín LF, Fernández-Parejo N, Menacho-Márquez M, Rodríguez-Fdez S, Robles-Valero J, Zumalave S, Fabbiano S, Pascual G, García-Pedrero JM, Abad A, García-Macías MC, González N, Lorenzano-Menna P, Pavón MA, González-Sarmiento R, Segrelles C, Paramio JM, Tubío JMC, Rodrigo JP, Benitah SA, Cuadrado M, Bustelo XR. VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. Nat Commun. 2020 Sep 22;11(1):4788. doi: 10.1038/s41467-020-18524-3. PMID: 32963234; PMCID: PMC7508832.
- Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53
Borini Etichetti CM, Arel Zalazar E, Cocordano N, Girardini J. (2020). Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53. Frontiers in Oncology, 10, 595034. https://doi.org/10.3389/fonc.2020.595034
- Design, synthesis and evaluation of novel levoglucosenone derivatives as promising anticancer agents
Tsai YH, Borini Etichetti CM, Cicetti S, Girardini JE, Spanevello RA, Suárez AG, Sarotti AM. (2020). Design, synthesis and evaluation of novel levoglucosenone derivatives as promising anticancer agents. Bioorganic & Medicinal Chemistry Letters, 30(14), 127247. https://doi.org/10.1016/j.bmcl.2020.127247
2019
- Immune response triggered by Trypanosoma cruzi infection strikes adipose tissue homeostasis altering lipid storage, enzyme profile and adipokine expressionGonzález, F. B., Villar, S. R., Toneatto, J., Pacini, M. F., Márquez, J., D’Attilio, L., Bottasso, O. A., Piwien-Pilipuk, G., & Pérez, A. R. (2019). Immune response triggered by Trypanosoma cruzi infection strikes adipose tissue homeostasis altering lipid storage, enzyme profile and adipokine expression. Medical Microbiology and Immunology, 208(5), 651–666. https://doi.org/10.1007/s00430-018-0572-z
- The importance of being scientifically cautious when criticizing the administration of vaccines: ‘retracted’ post truth
Barry, A., Bottasso, O. A., & Vicco, M. H. (2019). The importance of being scientifically cautious when criticizing the administration of vaccines: ‘retracted’ post truth. Immunotherapy, 11(1), 7–9. https://doi.org/10.2217/imt-2018-0062
- Diminished prolinemia in chronic chagasic patients: A new clue for disease pathology?
Rocha, S. C., Pérez, A. R., Beloscar, J., Bottasso, O., & Silber, A. M. (2019). Diminished prolinemia in chronic chagasic patients: A new clue for disease pathology? Molecules, 24(17), 3167. https://doi.org/10.3390/molecules24173167
- A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
Parodi, R. L., Lagrutta, M., Tortolo, M., Navall, E., Rodríguez, M. S., Sasia, G. F., De Candia, L. F., Gruvman, M. A., Bottasso, O., & Greca, A. A. (2019). A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period. PLoS ONE, 14(10), e0224299. https://doi.org/10.1371/journal.pone.0224299
- Modulation of the extraneuronal cholinergic system on main innate response leukocytes
Covantes-Rosales Carlos Eduardo, Toledo-Ibarra Gladys Alejandra, Díaz-Resendiz Karina Janice Guadalupe, Ventura-Ramón Guadalupe Herminia, Pavón Lenin, Becerril-Villanueva Enrique, Bauer Moisés Evandro, Bottaso Oscar, Girón-Pérez Manuel Iván. Modulation of the extraneuronal cholinergic system on main innate response leukocytes,Journal of Neuroimmunology, 327,2019, 22-35. ISSN 0165-5728. https://doi.org/10.1016/j.jneuroim.2019.01.008.
- Editorial: Hormones, Neurotransmitters, and T-Cell Development in Health and Disease
Pérez AR, Mendes-da-Cruz DA, Geenen V, Savino W. (2019). Editorial: Hormones, Neurotransmitters, and T-Cell Development in Health and Disease. Frontiers in Endocrinology, 10, 454. https://doi.org/10.3389/fendo.2019.00454
- Immune-endocrine interactions related to a high risk of infections in chronic metabolic diseases: The role of PPAR gamma
Silva AR, Gonçalves-de-Albuquerque CF, Pérez AR, Carvalho VF. (2019). Immune-endocrine interactions related to a high risk of infections in chronic metabolic diseases: The role of PPAR gamma. European Journal of Pharmacology, 854, 272-281. https://doi.org/10.1016/j.ejphar.2019.04.008
- Characterization of RHD locus polymorphism in D negative and D variant donors from Northwestern Argentina
Trucco Boggione C, Nogués N, González-Santesteban C, Mufarrege N, Luján Brajovich M, Mattaloni SM, Leri M, Biondi C, Muñiz-Diaz E, Castilho L, Cotorruelo C. (2019). Characterization of RHD locus polymorphism in D negative and D variant donors from Northwestern Argentina. Transfusion, 59(10), 3236-3242. https://doi.org/10.1111/trf.15504
- Glucocorticoids and sympathetic neurotransmitters modulate the acute immune response to Trypanosoma cruzi
Roggero E, Del Rey A, Wildmann J, Besedovsky H. Glucocorticoids and sympathetic neurotransmitters modulate the acute immune response to Trypanosoma cruzi. Ann N Y Acad Sci. 2019 Feb;1437(1):83-93. doi: 10.1111/nyas.13946. Epub 2018 Aug 8. PMID: 30088661
2018
- Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions
Pérez AR, Morrot A, Carvalho VF, de Meis J and Savino W (2018) Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions. Front. Endocrinol. 9:334. doi: 10.3389/fendo.2018.00334
- Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy
González, F., Villar, S., D’Attilio, L., Leiva, R., Marquez, J., Lioi, S., Beloscar, J., Bottasso, O., & Pérez, A. R. (2018). Dysregulated network of immune, endocrine and metabolic markers is associated to more severe human chronic Chagas cardiomyopathy. Neuroimmunomodulation, 25(3), 119–128. https://doi.org/10.1159/000491699
- Chronic Infections and the Hypothalamus-Pituitary-Adrenal Axis in the Context of Immune-Mediated Inflammation
Bottasso O. Chronic Infections and the Hypothalamus-Pituitary-Adrenal Axis in the Context of Immune-Mediated Inflammation. Advances in Neuroimmune Biology. 2018;7(1):79-89. doi:10.3233/NIB-170135
- The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: a better local profile in pleural fluid
D’Attilio L, Díaz A, Fernández RDV, Bongiovanni B, Santucci N, Dídoli G, Lioi S, Gardeñez W, Naninni JL, Del Rey A, Besedovsky H, Bottasso O, Bay ML. The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: a better local profile in pleural fluid. Int J Tuberc Lung Dis. 2018 Mar 1;22(3):321-327. doi: 10.5588/ijtld.17.0270. PMID: 29471911.
- Tuberculosis, the disrupted immune‑endocrine response and the potential thymic repercussion as a contributing factor to disease physiopathology
D’Attilio, L. D., Santucci, N. E., Bongiovanni, B., Bay, M. L., & Bottasso, O. A. (2018). Tuberculosis, the disrupted immune‑endocrine response and the potential thymic repercussion as a contributing factor to disease physiopathology. Frontiers in Endocrinology, 9, 214. http://dx.doi.org/10.3389/fendo.2018.00214
2017
- Trans-sialidase-based vaccine candidate protects against Trypanosoma cruzi infection, not only inducing an effector immune response but also affecting cells with regulatory/suppressor phenotype
Prochetto E, Roldán C, Bontempi IA, Bertona D, Peverengo L, Vicco MH, Rodeles LM, Pérez AR, Marcipar IS, Cabrera G. Trans-sialidase-based vaccine candidate protects against Trypanosoma cruzi infection, not only inducing an effector immune response but also affecting cells with regulatory/suppressor phenotype. Oncotarget. 2017 May 25;8(35):58003-58020. doi: 10.18632/oncotarget.18217. PMID: 28938533; PMCID: PMC5601629.
- Death of adrenocortical cells during murine acute T. cruzi infection is mediated by Fas-driven apoptosis
Ana R. Pérez, Flavia Lambertucci, Florencia B. González, Eduardo A. Roggero, Oscar A. Bottasso, Juliana de Meis, Maria T. Ronco, Silvina R. Villar. (2017).Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis. Brain, Behavior, and Immunity, 61, 142–153. https://doi.org/10.1016/j.bbi.2017.05.017
- miR-30c is specifically repressed in patients with active pulmonary tuberculosis
Spinelli, S. V., Fernández, R. D. V., Zoff, L., Bongiovanni, B., Díaz, A., D’Attilio, L., Santucci, N., Alvarez, T., Marchesini, M. M., Bogue, C., Bay, M. L., & Bottasso, O. A. (2017). miR-30c is specifically repressed in patients with active pulmonary tuberculosis. Tuberculosis (Edinburgh), 105, 73–79. https://doi.org/10.1016/j.tube.2017.04.004
- The clinical recovery of tuberculosis patients undergoing specific treatment is associated with changes in the immune and neuroendocrine responses Díaz, A., Bongiovanni, B., D’Attilio, L., Santucci, N., Dídoli, G., Fernández, R. D. V., Kovalevski, L., Lioi, S., Gardeñez, W., Brandan, N., Nannini, L. J., Besedovsky, H., Del Rey, A., Bottasso, O., & Bay, M. L. (2017). The clinical recovery of tuberculosis patients undergoing specific treatment is associated with changes in the immune and neuroendocrine responses. Pathogens and Disease, 75(7), ftx087. https://doi.org/10.1093/femspd/ftx087
- Genotyping approach for non-invasive foetal RHD detection in an admixed population
Boggione CT, Luján Brajovich ME, Mattaloni SM, Di Mónaco RA, García Borrás SE, Biondi CS, Cotorruelo CM. (2017). Genotyping approach for non-invasive foetal RHD detection in an admixed population. Blood Transfusion, 15(1), 66-73. https://doi.org/10.2450/2016.0228-15
- Clinical Significance of an Alloantibody against the Kell Blood Group Glycoprotein
Mattaloni SM, Arnoni C, Céspedes R, Nonaka C, Trucco Boggione C, Luján Brajovich ME, Trejo A, Zani N, Biondi CS, Castilho L, Cotorruelo CM. (2017). Clinical Significance of an Alloantibody against the Kell Blood Group Glycoprotein. Transfusion Medicine and Hemotherapy, 44(1), 53-57. https://doi.org/10.1159/00044838
- Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis
Singh KV, Tran TT, Nannini EC, Tam VH, Arias CA, Murray BE. Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis. Antimicrob Agents Chemother. 2017 Jun 27;61(7):e00324-17. doi: 10.1128/AAC.00324-17. PMID: 28483961; PMCID: PMC5487651.
2016
- An adverse immune‑endocrine profile in patients with tuberculosis and type 2 diabetes
Fernández, R. d. V., Díaz, A., D’Attilio, L. D., Bongiovanni, B., Santucci, N. E., Bay, M. L.,D. Bertola, H. Besedovsky, A. del Rey, Bottasso, O. A. (2016). An adverse immune‑endocrine profile in patients with tuberculosis and type 2 diabetes. Tuberculosis (Edinb), 101, 95–101. https://doi.org/10.1016/j.tube.2016.09.001
- Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment
González FB, Calmon-Hamaty F, Nô Seara Cordeiro S, Fernández Bussy R, Spinelli SV, D’Attilio L, et al. (2016) Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment. PLoS Negl Trop Dis 10(1): e0004285. doi:10.1371/journal.pntd.0004285
- Antibody profiles induced by Trypanosoma cruzi in chagasic patients with previous or current exposure to mycobacteria
Peverengo, L., Prochetto, E., Rodeles, L., Valenzuela, I., Marcipar, I. S., Bottasso, O., & Vicco, M. H. (2016). Antibody profiles induced by Trypanosoma cruzi in chagasic patients with previous or current exposure to mycobacteria. Pathogens and Disease, 74(9), ftw109. https://doi.org/10.1093/femspd/ftw109
- Combined analysis of cross-reacting antibodies anti-β1AR and anti-B13 in advanced stages of Chagas heart disease
Rodeles, L. M., Vicco, M. H., Bontempi, I. A., Siano, A., Tonarelli, G., Bottasso, O. A., Arias, P., & Marcipar, I. S. (2016). Combined analysis of cross-reacting antibodies anti-β1AR and anti-B13 in advanced stages of Chagas heart disease. Tropical Medicine & International Health, 21(12), 1545–1551. https://doi.org/10.1111/tmi.12791
- IgG Autoantibodies Induced by T. cruzi During Pregnancy: Correlation with Gravidity Complications and Early Outcome Assessment of the Newborns
Vicco, M. H., Rodeles, L., Capovilla, G. S., Perrig, M., Choque, A. G., Marcipar, I., Bottasso, O., Rodriguez, C., & Cuña, W. (2016). IgG autoantibodies induced by T. cruzi during pregnancy: Correlation with gravidity complications and early outcome assessment of the newborns. Maternal and Child Health Journal, 20(10), 2057–2064. https://doi.org/10.1007/s10995-016-2035-8
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The sympathetic nervous system affects the susceptibility and course of Trypanosoma cruzi infection
Roggero E, Pérez AR, Pollachini N, Villar SR, Wildmann J, Besedovsky H, Del Rey A. (2016). The sympathetic nervous system affects the susceptibility and course of Trypanosoma cruzi infection. Brain, Behavior, and Immunity, 58, 228-236. https://doi.org/10.1016/j.bbi.2016.07.163 - Weak D antigen expression caused by a novel RHD allele in Argentineans
Trucco Boggione C, Luján Brajovich ME, Gaspardi AC, Sippert E, Mattaloni SM, Leri M, Biondi C, Castilho L, Cotorruelo CM. (2016). Weak D antigen expression caused by a novel RHD allele in Argentineans. Transfusion, 56(11), 2895-2896. https://doi.org/10.1111/trf.13790
2015
- Marcipar IS. Efficacy of a trans-sialidase-ISCOMATRIX subunit vaccine candidate to protect against experimental Chagas disease
Bontempi IA, Vicco MH, Cabrera G, Villar SR, González FB, Roggero EA, Ameloot P, Callewaert N, Pérez AR, Marcipar IS. Efficacy of a trans-sialidase-ISCOMATRIX subunit vaccine candidate to protect against experimental Chagas disease. Vaccine. 2015 Mar 3;33(10):1274-83. doi: 10.1016/j.vaccine.2015.01.044. Epub 2015 Jan 25. PMID: 25625671.
- Immunoendocrine Interactions during HIV-TB Coinfection: Implications for the Design of New Adjuvant Therapies
Suarez GV, Vecchione MB, Angerami MT, Sued O, Bruttomesso AC, Bottasso OA, & Quiroga MF (2015). Immunoendocrine Interactions during HIV-TB Coinfection: Implications for the Design of New Adjuvant Therapies. BioMed Research International, 2015, 461093. https://doi.org/10.1155/2015/461093
- Effect of cortisol and/or DHEA on THP1-derived macrophages infected with Mycobacterium tuberculosis
Bongiovanni B, Mata-Espinosa D, D’Attilio L, Leon-Contreras JC, Marquez-Velasco R, Bottasso O, Hernandez-Pando R, & Bay ML (2015). Effect of cortisol and/or DHEA on THP1-derived macrophages infected with Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland), 95(5), 562–569. https://doi.org/10.1016/j.tube.2015.05.011
- The implication of pro-inflammatory cytokines in the impaired production of gonadal androgens by patients with pulmonary tuberculosis
Bini EI, D’Attilio L, Marquina-Castillo B, Mata-Espinosa D, Díaz A, Marquez-Velasco R, Ramos-Espinosa O, Gamboa-Domínguez A, Bay ML, Hernández-Pando R, & Bottasso O (2015). The implication of pro-inflammatory cytokines in the impaired production of gonadal androgens by patients with pulmonary tuberculosis. Tuberculosis (Edinburgh, Scotland), 95(6), 701–706. https://doi.org/10.1016/j.tube.2015.06.002
- HIV-TB coinfection impairs CD8(+) T-cell differentiation and function while dehydroepiandrosterone improves cytotoxic antitubercular immune responses
Suarez GV, Angerami MT, Vecchione MB, Laufer N, Turk G, Ruiz MJ, Mesch V, Fabre B, Maidana P, Ameri D, Cahn P, Sued O, Salomón H, Bottasso OA, & Quiroga MF (2015). HIV-TB coinfection impairs CD8(+) T-cell differentiation and function while dehydroepiandrosterone improves cytotoxic antitubercular immune responses. European journal of immunology, 45(9), 2529–2541. https://doi.org/10.1002/eji.201545545
- Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3(+) T cells
González FB, Villar SR, Fernández Bussy R, Martin GH, Pérol L, Manarin R, Spinelli SV, Pilon C, Cohen JL, Bottasso OA, Piaggio E, & Pérez AR (2015). IImmunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3(+) T cells. Brain, behavior, and immunity, 45, 219–232. https://doi.org/10.1016/j.bbi.2014.11.016
- The Role of High Mobility Group Box 1 Protein (HMGB1) in the Immunopathology of Experimental Pulmonary Tuberculosis
Hernández-Pando R, Barrios-Payán J, Mata-Espinosa D, Marquina-Castillo B, Hernández-Ramírez D, Bottasso OA, & Bini EI (2015). The Role of High Mobility Group Box 1 Protein (HMGB1) in the Immunopathology of Experimental Pulmonary Tuberculosis. PloS one, 10(7), e0133200. https://doi.org/10.1371/journal.pone.0133200
- Trypanosoma cruzi Infection through the Oral Route Promotes a Severe Infection in Mice: New Disease Form from an Old Infection?
Barreto-de-Albuquerque J, Silva-dos-Santos D, Pérez AR, Berbert LR, de Santana-van-Vliet E, Farias-de-Oliveira DA, Moreira OC, Roggero E, de Carvalho-Pinto CE, Jurberg J, Cotta-de-Almeida V, Bottasso O, Savino W, de Meis J. Trypanosoma cruzi Infection through the Oral Route Promotes a Severe Infection in Mice: New Disease Form from an Old Infection? PLoS Negl Trop Dis. 2015 Jun 19;9(6):e0003849. doi: 10.1371/journal.pntd.0003849. PMID: 26090667; PMCID: PMC4474863. doi: 10.1371/journal.pntd.0003849
- Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile
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