PUBLICACIONES 2023-2025

Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease

Pérez Ana R. , Bottasso Oscar A. , Santucci Natalia E. Front Endocrinol. 2025 Feb. doi: 10.3389/fendo.2025.1538376

Un empirista en pleno medioevo

Oscar Bottasso. 2025 Feb. Intramed

Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for inflammation and cardiac hypertrophy

González FB, Pacini A, Castro A, Lioi S, Villar SR, D'Attilio L, Leiva RD, Favaloro L, Bottasso OA, Vigliano CA, Pérez AR.  Front Endocrinol (Lausanne). 2025 Jan 30;16:1486772. doi: 10.3389/fendo.2025.1486772.

Activation of the Nrf2/HO-1 pathway restores N-acetylcysteine-induced impairment of the hypothalamus-pituitary-adrenal axis negative feedback by up-regulating GRα expression and down-regulating GRβ expression into pituitary glands

Chaves AS, Ventura RD, Pacini MF, Magalhães NS, Silva PMRE, Martins MA, Pérez AR, Carvalho VF. Front Endocrinol (Lausanne). 2025 Jan 27;16:1500630. doi: 10.3389/fendo.2025.1500630. 

Lack of differences in outcomes between three immunosuppression protocols in the first year post pediatric liver transplantation. A multicenter study.

Costaguta AC, Costaguta GA, Rumbo C, Gondolesi G, D'Agostino D, Pallito MB, Bottasso O, Álvarez F.Liver Transpl. 2024 Jul 2. doi: 10.1097/LVT.0000000000000427. Online ahead of print.

Isoprenylcysteine carboxyl methyltransferase (ICMT) promotes invadopodia formation and metastasis in cancer cells.

Borini Etichetti C, Arel Zalazar E, Di Benedetto C, Cocordano N, Valente S, Bicciato S, Menacho-Márquez M, Larocca MC, Girardini J.Biochimie. 2024 Jul;222:28-36. doi: 10.1016/j.biochi.2024.01.015. Epub 2024 Jan 30.

Characteristics of endemic human coronavirus infections during times of COVID-19 pandemic.

Crocci EE, Schreiner D, García EA, Nannini EC, Cobos M, Doubik P, Balbuena JP, Romandetta A, Cooke B, Alzogaray MF, Baumeister E, Mykietiuk A.Medicina (B Aires). 2024;84(1):102-107.

Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach.

Villar SR, Herreros-Cabello A, Callejas-Hernández F, Maza MC, Del Moral-Salmoral J, Gómez-Montes M, Rodríguez-Angulo HO, Carrillo I, Górgolas M, Bosch-Nicolau P, Molina I, Pérez-Molina JA, Monge-Maillo B, Bottasso OA, Beloscar J, Pérez AR, Fresno M, Gironès N.Sci Rep. 2024 Jan 12;14(1):1187. doi: 10.1038/s41598-024-51487-9.

Disarming mutant p53 oncogenic function.

Girardini JE, Marotta C, Del Sal G.Pharmacol Res. 2014 Jan;79:75-87. doi: 10.1016/j.phrs.2013.11.003. Epub 2013 Nov 15.

Ready for new waves: optimizing SARS-CoV-2 variants monitoring in pooled samples with droplet digital PCR.

Pacini A, Paredes F, Heckel S, Ibarra G, Petreli MV, Perez M, Agnella Y, Piskulic L, Allasia MB, Caprile L, Colaneri A, Sesma J. Front Public Health. 2024 Jan 12;11:1340420. doi: 10.3389/fpubh.2023.1340420. eCollection 2023.

Brain-Thymus Connections in Chagas Disease.

González FB, Savino W, Pérez AR.Neuroimmunomodulation. 2024;31(1):78-88. doi: 10.1159/000538220. Epub 2024 Apr 9.

Association between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease.

Ambrosio LF, Volpini X, Quiroz JN, Brugo MB, Knubel CP, Herrera MR, Fozzatti L, Avila Pacheco J, Clish CB, Takenaka MC, Beloscar J, Theumer MG, Quintana FJ, Perez AR, Motrán CC.Front Immunol. 2024 Jan 12;14:1267641. doi: 10.3389/fimmu.2023.1267641. eCollection 2023.

Systemic inflammatory Th1 cytokines during Trypanosoma cruzi infection disrupt the typical anatomical cell distribution and phenotypic/functional characteristics of various cell subsets within the thymus.

Viano ME, Baez NS, Savid-Frontera C, Baigorri RE, Dinatale B, Pacini MF, Bulfoni Balbi C, Gonzalez FB, Fozzatti L, Lidón NL, Young HA, Hodge DL, Cerban F, Stempin CC, Pérez AR, Rodriguez-Galán MC.Microbes Infect. 2024 Jul-Aug;26(5-6):105337. doi: 10.1016/j.micinf.2024.105337. Epub 2024 Apr 13.

Antibodies to SARS-CoV2 induced by vaccination and infection correlate with protection against the infection.

Flor N, García MI, Molineri A, Bottasso O, Diez C, Veaute C. Vaccine. 2023 Nov 22;41(48):7206-7211. doi: 10.1016/j.vaccine.2023.10.038. Epub 2023 Oct 24.

Impact of population mobility on the behavior of respiratory viruses during the COVID-19 pandemic.

Cobos M, Nannini EC, Balbuena JP, Crocci EE, Schreiner D, Garcia EA, Chapartegui S, Doubik P, Romandetta A, Cooke B, Alzogaray MF, Baumeister E, Mykietiuk A.Medicina (B Aires). 2023;83(5):719-726.

The long-term antibody response after SARS-CoV-2 prime-boost vaccination in healthy individuals. The positive influence of extended between-dose intervals and heterologous schedule.

Naidich G, Santucci NE, Pezzotto SM, Ceccarelli EA, Bottasso OA, Perichón AM.Front Immunol. 2023 Apr 17;14:1141794. doi: 10.3389/fimmu.2023.1141794. eCollection 2023.

Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle.

Kaufman CD, Farré C, Biscari L, Pérez AR, Alloatti A.Front Cell Dev Biol. 2023 Dec 21;11:1260423. doi: 10.3389/fcell.2023.1260423. eCollection 2023.

Lipophilic modification of salirasib modulates the antiproliferative and antimigratory activity.

Ballari MS, O J Porta E, Zalazar EA, Etichetti CMB, Padrón JM, Girardini JE, Labadie GR.Bioorg Med Chem. 2023 Sep 7;92:117417. doi: 10.1016/j.bmc.2023.117417. Epub 2023 Jul 17.

Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial.

O'Halloran JA, Ko ER, Anstrom KJ, Kedar E, McCarthy MW, Panettieri RA Jr, Maillo M, Nunez PS, Lachiewicz AM, Gonzalez C, Smith PB, de Tai SM, Khan A, Lora AJM, Salathe M, Capo G, Gonzalez DR, Patterson TF, Palma C, Ariza H, Lima MP, Blamoun J, Nannini EC, Sprinz E, Mykietiuk A, Alicic R, Rauseo AM, Wolfe CR, Witting B, Wang JP, Parra-Rodriguez L, Der T, Willsey K, Wen J, Silverstein A, O'Brien SM, Al-Khalidi HR, Maldonado MA, Melsheimer R, Ferguson WG, McNulty SE, Zakroysky P, Halabi S, Benjamin DK Jr, Butler S, Atkinson JC, Adam SJ, Chang S, LaVange L, Proschan M, Bozzette SA, Powderly WG; ACTIV-1 IM Study Group Members.JAMA. 2023 Jul 25;330(4):328-339. doi: 10.1001/jama.2023.11043.

Studies on the contribution of PPAR Gamma to tuberculosis physiopathology.

Díaz A, D'Attilio L, Penas F, Bongiovanni B, Massa E, Cevey A, Santucci N, Bottasso O, Goren N, Bay ML.Front Cell Infect Microbiol. 2023 Apr 28;13:1067464. doi: 10.3389/fcimb.2023.1067464. eCollection 2023.

The high identity of the Trypanosoma cruzi Group-I of trans-sialidases points them as promising vaccine immunogens.

Pacini MF, Perdomini A, Bulfoni Balbi C, Dinatale B, Herrera FE, Perez AR, Marcipar I.Proteins. 2023 Oct;91(10):1444-1460. doi: 10.1002/prot.26537. Epub 2023 Jun 16.

Comparative analysis of clinical characteristics, evolution and mortality of hospitalized patients with COVID-19 during the first and second wave of the pandemic (ECCOVID Study).

Córdova E, Mykietiuk A, De Vedia L, Bacelar B, Cáceres MF, Nemirovsky C, Contreras R, Alzogaray MF, Nannini E, Consalvo MF, Soler Puy L, Scapellato PG, Barcelona L, Golikow ML, Piñeiro MF, Miño HJ, Cabral M, Lamponi Tappata L, Lopardo G, Sued O, Stryjewski ME; Grupo ECCOVID-SADI.Medicina (B Aires). 2023;83(4):551-557.

Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia.

Holland TL, Cosgrove SE, Doernberg SB, Jenkins TC, Turner NA, Boucher HW, Pavlov O, Titov I, Kosulnykov S, Atanasov B, Poromanski I, Makhviladze M, Anderzhanova A, Stryjewski ME, Assadi Gehr M, Engelhardt M, Hamed K, Ionescu D, Jones M, Saulay M, Smart J, Seifert H, Fowler VG Jr; ERADICATE Study Group.N Engl J Med. 2023 Oct 12;389(15):1390-1401. doi: 10.1056/NEJMoa2300220. Epub 2023 Sep 27.

Intranasal trans-sialidase-based vaccine against Trypanosoma cruzi triggers a mixed cytokine profile in the nasopharynx-associated lymphoid tissue and confers local and systemic immunogenicity.

Pacini MF, Balbi CB, Dinatale B, González FB, Prochetto E, De Hernández MA, Cribb P, Farré C, Espariz M, Blancato VS, Magni C, Marcipar I, Pérez AR. Acta Trop. 2023 May;241:106889. doi: 10.1016/j.actatropica.2023.106889. Epub 2023 Mar 7.

D-phenotype caused by a novel RHCE null allele.

Principi C, Trucco Boggione C, Ensinck A, Posner V, Luján Brajovich M, Stettler S, Mattaloni S, Biondi C, Cotorruelo C. Transfusion. 2024 Feb;64(2):E3-E5. doi: 10.1111/trf.17698. Epub 2024 Jan 5.

Synuclein Proteins in Cancer Development and Progression.

Zanotti LC, Malizia F, Cesatti Laluce N, Avila A, Mamberto M, Anselmino LE, Menacho-Márquez M. Biomolecules. 2023 Jun 12;13(6):980. doi: 10.3390/biom13060980.

Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents.

Bruna-Haupt EF, Perretti MD, Garro HA, Carrillo R, Machín F, Lorenzo-Castrillejo I, Gutiérrez L, Vega-Hissi EG, Mamberto M, Menacho-Marquez M, Fernández CO, García C, Pungitore CR.ACS Omega. 2023 Jul 13;8(29):26479-26496. doi: 10.1021/acsomega.3c03181. eCollection 2023 Jul 25.

Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers.

Anselmino LE, Baglioni MV, Reynoso G, Rozados VR, Scharovsky OG, Rico MJ, Menacho-Márquez M.Sci Rep. 2023 May 16;13(1):7923. doi: 10.1038/s41598-023-34793-6.
Di Benedetto C, Borini Etichetti C, Cocordano N, Cantoia A, Arel Zalazar E, Bicciato S, Menacho-Márquez M, Rosano GL, Girardini J. Front Mol Biosci. 2023 Sep 14;10:1145279. doi: 10.3389/fmolb.2023.1145279. eCollection 2023.

The relationship between host defense peptides and adrenal steroids. An account of reciprocal influences.

Díaz A, Diab M, Mata-Espinosa D, Bini E, D'Attilio L, Bottasso O, Hernández-Pando R, Bay ML,Bongiovanni B. Cytokine. 2023 Aug;168:156229. doi: 10.1016/j.cyto.2023.156229. Epub 2023 May 25.

Factors associated with mortality among hospitalized patients with COVID-19 disease treated with convalescent plasma.

Perichon AM, Acosta A, Di Tulio L, Munuce MJ, Pezzotto S, Bottasso O, Nannini EC.mBio. 2023 Dec 19;14(6):e0177723. doi: 10.1128/mbio.01777-23. Epub 2023 Nov 8.